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Tamoxifen is a standard therapeutical treatment in patients with estrogen
receptor positive breast carcinoma. However, less than 50% of estrogen receptor
 …15 Aug 2012 … The impact of PTEN tumor suppressor gene on acquiring resistance to tamoxifen
treatment in breast cancer patients. Tanic N(1), Milovanovic Z, …18 Dec 2010 … Role of PTEN promoter methylation in tamoxifen-resistant breast cancer cells.
Phuong NT(1), Kim SK, Lim SC, Kim HS, Kim TH, Lee KY, Ahn …14 May 2014 … MTDH Mediates Estrogen-Independent Growth and Tamoxifen Resistance by
Down-Regulating PTEN in MCF-7 Breast Cancer Cells. Xu C.a, b …overcome tamoxifen resistance in breast cancer patients. © 2016 The Authors.
….. PTEN levels were diminished in MCF-7-Tam-R cells. In addition, expression
of …Integrated molecular analysis of Tamoxifen-resistant invasive lobular breast
cancer … IDC; these include higher rates of PTEN loss, FOXA1 mutation, and
AKT …Tamoxifen (TAM) resistance is a serious clinical problem in the treatment of
breast cancer. Here, we found that S-adenosylmethionine (SAM) and DNA …6 Feb 2017 … MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT …… MicroRNA-
221/222 confers tamoxifen resistance in breast cancer by …Lower expression of ERβ is found in tamoxifen-resistant tumors, and high levels
… PTEN is a tumor suppressor whose expression is often lost in breast cancers …21 Apr 2014 … Using our in vitro model of tamoxifen resistance, we demonstrated that … For
silencing of RB1, PTEN, and CDKN1A, pools of four small …4 Jun 2016 … Numerous molecular mechanisms of tamoxifen resistance have been ….. An
integrative genomic and proteomic analysis of PIK3CA, PTEN, and …This tri-allelic mouse model develops induced malignant melanomas following
topical application of tamoxifen.1 Aug 2018 … In human breast cancer, expression of the tumor suppressor PTEN and the cell …
in stromal PTEN and radiation resistance would be game-changing to the field. …
Hedgehog Pathway Key in Tamoxifen-Resistant Breast CA.R-519a targets central nodes (PTEN, CDKN1A, and RB1) from PI3K and cell
cycle network leading to increased proliferation and tamoxifen resistance.loss of PTEN in HER2-overexpressing cancers correlates with a lower response
to …. fulvestrant, and tamoxifen resistance, low concentrations of everolimus …tamoxifen-resistant tumors, and high levels of ERb are … mediated tamoxifen
resistance [25]. … HER2/HER3 signaling and upregulation of PTEN and,.10 Jan 2014 … Here we will explore those that mediate tamoxifen resistance, ….. PTEN is
frequently hypermethylated in drug-resistant breast cancer, and this …Phosphatase and tensin homologue deleted on chromosome 10 (PTEN), also
referred to as … Hedgehog Pathway Key in Tamoxifen-Resistant Breast CA.Our aim is to study the DNA damage induced by TMX resistance in ER+ breast …
involved in DNA damage, we assessed PTEN expression by Western blot.PTEN inactivating alterations. – 14% ILC v … Evidence for Tamoxifen Resistance –
. ILC Models …. Overexpression of FGFR4 in endocrine resistant ILC. P. LTED.